Funding will advance company’s two lead programs through clinical proof-of-mechanism, as well as enable continued growth of its biologics pipeline and expansion of its IMPACT platform

The financing brings total capital raised by the company to $222 million

December 04, 2023 04:00 AM Pacific Standard Time

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Seismic Therapeutic, Inc., the machine learning immunology company, today announced that it has closed a $121 million Series B financing. The Series B was led by new investor Bessemer Venture Partners with participation from other new investors, Amgen Ventures, Codon Capital, Alexandria Venture Investments, Gaingels and GC&H, as well as existing investors, Timothy A. Springer, Lightspeed Venture Partners, Polaris Partners, Boxer Capital, GV, Samsara BioCapital, and management and founders.

“We look forward to collaborating with the Seismic team to realize the full potential of its unique approach to immunology drug development, enabled by machine learning.”

Proceeds from the Series B financing will be used to advance through Phase 1 proof-of-mechanism trials with Seismic’s two lead programs: a pan‑immunoglobulin (Ig) G protease sculpting (Sc) enzyme candidate (S-1117) and a PD-1 agonist:Fc gamma receptor IIb selective Dual-cell Bidirectional (DcB) antibody candidate (S-4321). In addition, the Series B will enable the continued growth of the company’s pipeline in both the IgSc and DcB product areas, beyond the lead programs. The funding will also enable the company to further expand its proprietary machine learning-enabled IMPACT platform with the development and implementation of additional cutting-edge methods to enhance biologics drug discovery in immunology. Concurrent with the financing, Andrew Hedin, MBA, biotech and healthcare partner of Bessemer Venture Partners, will join Seismic’s board of directors.

“Seismic has made impressive achievements in a short time integrating the power of machine learning with its deep drug development expertise to create two differentiated lead programs, each offering a compelling opportunity to address unmet medical needs in autoimmune diseases in a new way,” said Mr. Hedin. “We look forward to collaborating with the Seismic team to realize the full potential of its unique approach to immunology drug development, enabled by machine learning.”

Since the company’s launch and announcement of its Series A round, Seismic has advanced two programs into IND-enabling studies. This progress resulted from Seismic’s integration of leading-edge machine learning into drug development in a specific area – biologics for immunology – powered by a diverse team of drug developers and machine learning innovators. With this approach and its IMPACT platform, Seismic has rapidly engineered novel biologics with drug-like properties using multi-parameter optimization. For its lead IgSc enzyme program, Seismic engineered novel pan-IgG proteases with reduced B cell and T cell immunogenicity and chemical liabilities while maintaining enzyme activity and stability, creating a protease therapeutic to address multiple pathogenic mechanisms in a single drug for the treatment of acute and chronic autoantibody mediated diseases. Seismic designed its lead DcB antibody program to optimize the targeting of multiple cell types that drive pathogenesis of autoimmune diseases, specifically engaging T cells via PD-1 agonism and antigen presenting cells via the inhibitory Fc gamma receptor.

“We are delighted to secure the support of such a strong syndicate of investors who believe in Seismic’s ability to pioneer a new era of immunology drug development integrating machine learning,” said Jo Viney, PhD, Founder, President and CEO of Seismic Therapeutic. “This financing enables us to continue our momentum and advance both of our exciting lead programs into the clinic. We believe the time is right to harness advances in machine learning to discover the next generation of biologics drugs to improve the lives of patients with autoimmune diseases.”

About the IMPACT Platform

The IMPACT platform “parallelizes” interdisciplinary components of drug discovery to generate drug molecules on an unprecedented scale that are engineered to be better therapeutics to treat autoimmune diseases. Comprehensive integration of machine learning with protein engineering, structural biology and translational immunology enables the accelerated design and analysis of vast numbers of proteins and protein modifications. This parallelized process bypasses the trial and error methods of conventional biologics development, enabling simultaneous optimization for biologic function, reduced immunogenicity and developability, resulting in the creation of novel biologics with superior properties.

About Seismic Therapeutic

Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X (formerly Twitter) @Seismic_Tx.

About Bessemer Venture Partners

Bessemer Venture Partners helps entrepreneurs lay strong foundations to build and forge long-standing companies. With more than 145 IPOs and 300 portfolio companies in the enterprise, consumer and healthcare spaces, Bessemer supports founders and CEOs from their early days through every stage of growth. Bessemer’s global portfolio has included Pinterest, Shopify, Twilio, Yelp, LinkedIn, PagerDuty, DocuSign, Wix, Fiverr, and Toast and has $20 billion of assets under management. Bessemer has teams of investors and partners located in Tel Aviv, Silicon Valley, San Francisco, New York, London, Hong Kong, Boston, and Bangalore. Born from innovations in steel more than a century ago, Bessemer’s storied history has afforded its partners the opportunity to celebrate and scrutinize its best investment decisions (see Memos) and also learn from its mistakes (see Anti-Portfolio).

Contacts

Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

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